Schizophrenia Treatment Outcomes by Amresh Shrivastava & Avinash De Sousa

Author:Amresh Shrivastava & Avinash De Sousa
Language: eng
Format: epub
ISBN: 9783030198473
Publisher: Springer International Publishing

Future Directions

Overall, there is no clear evidence base for treatment of CHR/UHR individuals. With respect to pharmacological strategies, the use of second-generation antipsychotics is greatly limited by adverse effects that interfere with adherence. Glutamatergic strategies appear to have efficacy specifically for negative symptoms and cognitive deficits. Among psychological treatments, cognitive behavioral therapy holds promise, but such studies have been limited by low conversion rates to psychosis, such that there may be a nonspecific effect of clinical contact that is the operative ingredient. Cognitive remediation is particularly promising, as it has shown efficacy in improving cognition, with concomitant improvement in functioning. There are now clinical trials underway for exercise, which may be effective. Further, neurostimulation has not yet been tried, but a circuit-based approach to treatment, alone or in conjunction with cognitive remediation, may hold particular promise.

References

1.

Insel TR. Rethinking schizophrenia. Nature. 2010;468:187–93.PubMed

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